1-alkyl-2-aminotetralin derivatives

US5286747A · kind A · utility

Assignee

• Per A. E. Carlsson · SE

Inventors

• Folke L. Arvidsson · Uppsala, SE
• Per A. E. Carlsson · Göteborg, SE
• Uli A. Hacksell · Uppsala, SE
• John S. M. Hjorth · Göteborg, SE
• Anette Johansson · Järlåsa, SE
• Per L. Lindberg · Mölndal, SE
• John L. G. Nilsson · Tullinge, SE
• Domingo Sanchez · Floda, SE
• Hakan V. Wikstrom · Mölndal, SE

Key dates

• Filing date: Sep 29, 1989
• Grant date: Feb 15, 1994
• Expiry date: Sep 29, 2009

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula ##STR1## wherein R.sup.3 and the NR.sup.1 R.sup.2 group are in a cis-position to each other and wherein Y is OH, R.sup.4 COO, (R.sup.5).sub.2 NCOO or R.sup.6 O either in position 5 or position 7, whereby R.sup.4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R.sup.5 is an alkyl group having 1-5 carbon atoms and R.sup.6 is an allyl or benzyl group, R.sup.1 is hydrogen or an alkyl group having 1-3 carbon atoms, R.sup.2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenylalkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R.sup.3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.