Boron-gadolinium compounds and method of conducting imaging and/or neutron capture therapy with same
US5286853A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 11, 1992 |
| Grant date | Feb 15, 1994 |
| Priority date | — |
| Expiry date | Sep 11, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A gadolinium (3.sup.+) complex of polyamine polyacetate, comprising a polyamine nucleus having a pendant boron-containing substituent on one of the nitrogen or carbon atoms of the polyamine nucleus. The boron-gadolinium compound may suitably be of the formula: ##STR1## wherein: is a polyamine coordination structure capable of covalently bonding the substitutents R.sub.1, R.sub.2, R.sub.3 and R.sub.4 and of complexing with Gd; PA0 R.sub.1, R.sub.2, and R.sub.3 are independently selected from carboxyl, carboxylic salt groups, carboxylic ester groups, and carboxylate anion; PA0 R.sub.4 is a boron-containing group; and PA0 x is a number from zero to 4. Also disclosed is a method of treating a tumor-bearing mammalian subject by boron neutron capture therapy wherein the boron drug employed in such treatment comprises a boron-gadolinium compound, and a method of conducting sequential imaging and NCT treatment of a tumor tissue site in the corporeal structure of a mammalian subject, comprising administering to the mammalian subject an MRI imagingly- and NCT treatingly-effective amount of an effective boron-gadolinium compound, visualizing the tumor tissue site by MRI, and treating the tumo…
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