Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5288514A · kind A · utility
815Cited by
3References
18Claims
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Assignee
Inventor
Key dates
| Filing date | Sep 14, 1992 |
| Grant date | Feb 22, 1994 |
| Priority date | — |
| Expiry date | Sep 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B60/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods, compositions, and devices for synthesis of therapeutically useful compounds. The invention provides a rapid approach for combinatorial synthesis and screening of libraries of derivatives of therapeutically important classes of compounds such as benzodiazepines, prostaglandins and .beta.-turn mimetics. In order to expediently synthesize a combinatorial library of derivatives based upon these core structures, general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.