2-,3-,8-and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating osteoporosis
US5288719A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 21, 1993 |
| Grant date | Feb 22, 1994 |
| Priority date | — |
| Expiry date | Jan 21, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D267/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a method for treating osteoporosis in a mammal comprising administering to said mammal a therapeutically-effective amount of a 2-, 3-, 8- and/or 10-substituted dibenzoxazepine compound having a structure of the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, wherein: X is --NH-- or --CH.sub.2 --; PA1 Y is PA2 (1) --CH.sub.2 -- when X is --NH--, and PA2 (2) --NH-- when X is --CH.sub.2 --; PA1 R.sup.1 is hydrogen, halogen or --OR.sup.4 ; PA1 R.sup.4 is hydrogen, alkyl or ##STR2## Z is oxygen, sulfur, --SO--, --SO.sub.2 -- or --NR.sup.5 --; R.sup.5 is hydrogen or t-butyloxycarbonyl; PA1 R.sup.2 is hydrogen, halogen or trifluoromethyl; PA1 R.sup.3 is hydrogen, halogen, aryl, heteroaryl in which the heteroatoms are selected from oxygen, nitrogen and/or sulfur, or --NR.sup.6 R.sup.7 ; PA1 R.sup.6 and R.sup.7 are each independently hydrogen or alkyl; PA1 R.sup.8 is alkyl, aryl or ##STR3## R.sup.9 and R.sup.10 are each independently hydrogen or alkyl, or when taken together form N-morpholino or 4-methyl-N-piperazinyl; PA1 m and n are each independently integers of from 0 to 3; and PA1 P is 0 or 1, provided that p is not 1 when m is 0.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.