A composition and a method of using veratridine and epinephrine as a local anesthetic
US5288723A · kind A · utility
4Cited by
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6Claims
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Key dates
| Filing date | Oct 22, 1991 |
| Grant date | Feb 22, 1994 |
| Priority date | — |
| Expiry date | Oct 22, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/445
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of using veratridine to inhibit nerve impulses, and a composition of matter including veratridine and epinephrine, is provided. Application of veratridine proximal to a nerve causes depolarization of the nerve membrane, thereby blocking transmission of nerve impules. C-fiber selectivity is demonstrated in vitro in rabbit vagus nerves. Veratridine displays extended anesthetic activity over long periods of time when compared to similar local anesthetics, with no local toxicity. Systemic toxicity is reduced by co-injection with epinephrine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.