Enantiomeric resolution of 4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone
US5288916A · kind A · utility
9Cited by
1References
19Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 25, 1993 |
| Grant date | Feb 22, 1994 |
| Priority date | — |
| Expiry date | Mar 25, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C45/85
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is disclosed a method of separating enantiomers of 4-(3',4'-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenone comprising contacting the same with a homogeneous or nonhomogeneous liquid mixture of solvent and water, the mixture containing substantially pure and unsupported gamma-cyclodextrin or its derivatives. Also disclosed are methods of further enantiomerically enriching solid mixtures obtained from the enantiomer separation method and further extracting one enantiomer by solvent extraction of the solid mixtures obtained.
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