Phenyl substituted 2-thiazolyl tetrazolium salt indicators

US5290536A · kind A · utility

Assignee

• Miles Inc. · US

Inventors

• Jürgen Köcher · Cologne, DE
• Klaus Wehling · Wuppertal, DE

Key dates

• Filing date: Nov 10, 1992
• Grant date: Mar 1, 1994
• Expiry date: Nov 10, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/184
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Phenyl substituted 2-thiazolyl tetrazolium salt compounds characterized by a reflectance spectrum exhibiting an extended plateau above about 600-650 nm. Such compounds are useful as chromogenic indicators for reducing substances such as NADH. The reflectance plateau confers improved accuracy to analytical assays, particularly for the determination of analytes of medical diagnostic significance, in which a colorimetric response on a reagent carrier matrix is measured by reflectance.