4-(4-imidazolyl) piperidines substituted at position 1, their preparation and also their therapeutic applications

US5290790A · kind A · utility

Assignees

• National De La Sante et De La Recherche Medicale · FR
• BIOPROJET · FR
• Universite De Caen - Esplanade De La Faix · FR

Inventors

• Jean-Michel Arrang · Gif-sur-Yvette, FR
• Monigue Garborg · Paris, FR
• Jean-Charles Lancelot · Bayeux, FR
• Jeanne-Marie Lecomte · Paris, FR
• Max Robba · Paris, FR
• Jean-Charles Schwartz · Paris, FR

Key dates

• Filing date: Dec 30, 1991
• Grant date: Mar 1, 1994
• Expiry date: Dec 30, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds correspond to the general formula ##STR1## in which R.sub.1 represents a hydrogen atom or a group --COR.sub.2, in which R.sub.2 represents a benzene ring, cyclopentylmethyl, cyclohexylmethyl, cyclopentylethyl or cyclohexylethyl groups or cyclopentylamine, cyclohexylamine or phenylamine, chlorophenylamine or dichlorophenylamine groups; R represents a hydrogen atom or a group COR.sub.3, in which R.sub.3 represents an aliphatic group, a cyclane or benzene ring-system, a group a group (CH.sub.2).sup.m R.sub.4, a group --CH.dbd.CHR.sub.8 or a secondary amine group --NH(CH.sub.2).sub.n R.sub.g ; R also represents a hydroxyalkenyl group: ##STR2##