Substituted urea compound and use
US5290795A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 17, 1992 |
| Grant date | Mar 1, 1994 |
| Priority date | — |
| Expiry date | Aug 17, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D453/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
New substituted urea compounds of formula I, or a pharmaceutically acceptable salt thereof: ##STR1## wherein A is ##STR2## wherein R.sup.3 is an oxadiazol, substituted with C.sub.1-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.2-8 alkynyl, C.sub.3-7 cycloalkyl, benzyl, phenyl, C.sub.1-6 -alkoxy, C.sub.1-6 -alkylthio, amino or alkylamino; PA1 R.sup.2 is --H or lower alkyl; PA1 X is O or S; PA1 and R.sup.1 is a group of formula II, III, IV or V ##STR3## where n is 2 or 3, P is 1 or 2, q is 1 to 3, r is 1-3 and R.sup.4 and R.sup.5 are H,C.sub.1-7 alkyl or C.sub.3-6 cycloalkyl; and N-oxides thereof. The compounds are useful in pharmaceutical preparations for treating psychotic disorders, nausea and vomiting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.