Heteroaryl derivatives of monocyclic beta-lactam antibiotics

US5290929A · kind A · utility

Assignee

• E.R. SQUIBB & SONS. INC. · US

Inventors

• William H. Koster · Ringoes, US
• Joseph E. Sundeen · Yardley, US
• Henner Straub · Regensburg, DE
• Peter H. Ermann · Donaustauf, DE
• Uwe D. Treuner · Etterzhausen, DE
• Kent Amsberry · Plainsboro, US
• Michael Fakes · Plainsboro, US
• Sailesh A. Varia · Plainsboro, US

Key dates

• Filing date: Sep 8, 1992
• Grant date: Mar 1, 1994
• Expiry date: Sep 8, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.