Facile condensation of methylbenzoxazoles with aromatic aldehydes
US5290941A · kind A · utility
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Key dates
| Filing date | Oct 14, 1992 |
| Grant date | Mar 1, 1994 |
| Priority date | — |
| Expiry date | Oct 14, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An efficient process for the preparation of styrylbenzoxazoles and derivatives thereof comprises reacting a methylbenzoxazole with an aromatic aldehyde in the presence of strong base at low temperature, followed by warming. The condensation products are inhibitors of H.sup.+ K.sup.+ -ATPase, and are also useful as penultimate compounds in the preparation of inhibitors of HIV reverse transcriptase.
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