Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
US5290946A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 23, 1992 |
| Grant date | Mar 1, 1994 |
| Priority date | — |
| Expiry date | Nov 23, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for synthesizing compounds of the formula ##STR1## utilizing, as intermediates, oxalyl chloride or bromide and compounds of the formulae R.sub.1 R.sub.2 N--CHO and CH.sub.2 .dbd.CH--O--R.sub.10 are processes for synthesizing compounds of the formula ##STR2## utilizing, as intermediates, compounds of Formula I wherein R.sub.1 is phenyl or substituted phenyl or intermediates in the synthesis of the compounds of formula I which intermediates have the formula ##STR3## wherein R.sub.1 is C.sub.1-3 alkyl, phenyl or phenyl substituted by 1 to 3 substituents each of which is independently C.sub.1-3 alkyl, C.sub.1-3 alkoxy, fluoro, chloro, bromo or nitro (maximum of two nitro groups), PA0 R.sub.2 is C.sub.1-3 alkyl, PA0 R.sub.10 is C.sub.1-6 alkyl, PA0 X.sup..crclbar. is chloride or bromide, and PA0 R.sub.3 -R.sub.6 are as defined in the specification. The compounds of Formula II are intermediates in the synthesis of known HMB-CoA reductase inhibitors which inhibit the biosynthesis of cholesterol and are useful as antihyperchloesterolemic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.