Process for the stereoselective preparation of phenylisoserine derivatives used in making taxols
US5290957A · kind A · utility
23Cited by
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10Claims
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Key dates
| Filing date | Nov 20, 1992 |
| Grant date | Mar 1, 1994 |
| Priority date | — |
| Expiry date | Nov 20, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A stereoselective process for preparing phenylisoserine derivatives is disclosed. Benzylamine is reacted with an agent for introducing a phenyl or a t-butoxycarbonyl group. The product undergoes double anionization and then is reacted with acrolein to provide a mixture of alcohol syn and anti diasteroisomers. The syn isomer is isolated by chromatography. Whereupon, the hydroxyl is protected and the product is oxidized to provide the phenylisoserine derivative.
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