Azlactone-functional substrates, corneal prostheses, and manufacture and use thereof

US5292514A · kind A · utility

Assignee

• Minnesota Mining and Manufacturing Company · US

Inventors

• John T. Capecchi · Oakdale, US
• Steven M. Heilmann · Afton, US
• Larry R. Krepski · White Bear Lake, US
• Oh-Seung Kwon · Seojong-myeon, KR
• David B. Olson · Austin, US

Key dates

• Filing date: Jun 24, 1992
• Grant date: Mar 8, 1994
• Expiry date: Jun 24, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2/15
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Azlactone-functional substrates, (especially hydrogels), mammalian body implants, and methods of making and using them are disclosed. The azlactone-functional substrates are the reaction product of substrates having azlactone-reactive nucleophilic surfaces and a multi-functional azlactone composition having at least two azlactone moieties, where at least one moiety covalently couples to the azlactone-reactive nucleophilic surface and at least one moiety remains available for further nucleophilic reaction, such as with a biologically active material. A preferred use of azlactone-functional hydrogel is as the optical element of a corneal prosthesis which enhances epithethial cell growth.