Morpholinoalkylindenes as antiglaucoma agents
US5292736A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 26, 1993 |
| Grant date | Mar 8, 1994 |
| Priority date | — |
| Expiry date | Feb 26, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/535
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## wherein Alk is lower-alkylene; PA1 R.sub.1 is hydrogen, lower-alkyl, Ar or ArCOO; PA1 R.sub.2 is hydrogen or lower-alkyl; PA1 R.sub.3 and R.sub.4 are the same or different hydrogen, fluoro, chloro, bromo, hydroxy, lower-alkoxy, lower-alkyl, or trifluoromethyl; PA1 Ar is phenyl, naphthyl, anthryl, 2-phenylethenyl or a 5- or 6-membered monocyclic or 9- or 10-membered bicyclic fused aromatic heterocyclic ring containing carbon and one or two heteroatoms independently selected from oxygen, nitrogen and sulfur, or such carbocyclic or heterocyclic rings substituted with from 1 to about 3 of lower-alkoxy, lower-alkyl, lower-alkylthio, lower-alkyl sulfinyl, lower-alkyl sulfonyl, hydroxy, cyano, amino, lower-alkylamino, dilower-alkylamino or halo; PA1 or pharmaceutically acceptable acid addition salts thereof are useful as analgesics and in the treatment of glaucoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.