Substituted mandelic acid derivatives and their use in medicaments

US5292769A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Klaus-Helmut Mohrs · Wuppertal, DE
• Siegfried Raddatz · Hanerau-Hademarschen, DE
• Michael Matzke · Wuppertal, DE
• Romanis Fruchtmann · Cologne, DE
• Armin Hatzelmann · Konstanz, DE
• Christian Kohlsdorfer · Lechenich, DE
• Reiner Muller-Peddinghaus · Bensberg, DE
• Pia Theisen-Popp · Bensberg, DE

Key dates

• Filing date: Aug 21, 1992
• Grant date: Mar 8, 1994
• Expiry date: Aug 21, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in medicaments, in particular for medicaments which inhibit leukotriene synthesis.