Process for the stereoselective preparation of 5-substituted delta-lactones and use thereof

US5292898A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Peter Hammann · Kelkheim, DE
• Susanne Grabley · Königstein, DE
• Ernold Granzer · Kelkheim, DE
• Yvonne Romeyke · Groß-Gerau, DE

Key dates

• Filing date: Sep 1, 1992
• Grant date: Mar 8, 1994
• Expiry date: Sep 1, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C49/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the stereoselective preparation of 5-substituted .delta.-lactones of the formulae Ia, Ib, Ic and Id ##STR1## in which R.sup.1 is a straight-chain or branched alkyl or alkenyl group or methylhydroxy, novel 5-substituted .delta.-lactones and novel intermediates, and use thereof as pharmaceuticals having cholesterol synthesis-inhibiting action, fragrances and flavorings is described.