Phenyalkylaminoalkyl compounds and pharmaceutical compositions containing them

US5294638A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Insa Hell · Hannover, DE
• Ulf Preuschoff · Laatzen, DE
• Hermann Kraehling · Sehnde, DE
• Samuel David · Dorval, CA
• Ivan Ban · Hannover, DE
• Marie-Odile Christen · Paris, FR

Key dates

• Filing date: Jan 19, 1993
• Grant date: Mar 15, 1994
• Expiry date: Jan 19, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/78
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pharmacologically active compounds corresponding to the general formula I: ##STR1## wherein m represents 1-4, PA0 n represents 2-5, PA0 R.sup.1 is hydrogen or lower alkyl, PA0 R.sup.2 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl, and PA0 R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen, or PA0 R.sup.2 and R.sup.3 are linked to adjacent carbon atoms and together form an alkylenedioxy group with 1-2 carbon atoms, PA0 R.sup.4 represents a saturated monocyclic or bicyclic hydrocarbon radical derived from terpenes and having 10 or 11 hydrocarbon atoms, and PA0 Z represents oxygen, an N--R.sup.5 group, wherein R.sup.5 is lower alkyl, or if R.sup.4 is a dihydronopyl radical, Z may also be sulfur, and their acid addition salts.