Calcification-resistant synthetic biomaterials
US5296583A · kind A · utility
38Cited by
1References
8Claims
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Assignee
Inventor
Key dates
| Filing date | Jul 9, 1992 |
| Grant date | Mar 22, 1994 |
| Priority date | — |
| Expiry date | Jul 9, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/02
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or in-dwelling use in a human or animal body. Illustratively, reaction conditions utilizing bi- or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.