Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5296591A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 12, 1991 |
| Grant date | Mar 22, 1994 |
| Priority date | — |
| Expiry date | Dec 12, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The trifluoromethylketone derivatives (I) and pharmaceutically acceptable salts thereof have a human leukocyte elastase inhibiting activity and are useful as human leukocyte elastase inhibitors for treating or preventing degenerative diseases. The trifluoromethylketone derivatives (I) have the following formula: ##STR1## wherein R.sup.1 is C.sub.1-6 alkyl which has one or two substituents selected from carboxy, esterified carboxy and di-C.sub.1-6 alkylcarbamoyl; phenyl(C.sub.1-6) alkyl, the phenyl moiety of which may have halogen or nitro or amino substituents and the alkyl moiety of which may have carboxy or esterified carboxy substituents; halo-phenyl; morpholino; or morpholino(C.sub.1-6) alkyl, PA0 R.sup.2 and R.sup.3 are each C.sub.1-6 alkyl, PA0 X is -- or --NH--, and PA0 Y is ##STR2## and pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.