Detection of morphine using morphine dehydrogenase
US5298414A · kind A · utility
11Cited by
3References
8Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 12, 1991 |
| Grant date | Mar 29, 1994 |
| Priority date | — |
| Expiry date | Nov 12, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/44
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Two enzymes, one an acetylmorphine carboxyesterase (AMCE), the other a morphine dehydrogenase (MDH), have been isolated from bacteria. The AMCE degrades heroin to morphine and the MDH oxidises morphine to morphinone, with the aid of a cofactor. These reactions are used in detection of heroin (using the two reactions coupled together) or morphine. The enzymes can be incorporated in sensors for this purpose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.