Derivatives of endogenous mediators, their salts, method of preparation, applications and compositions in which they are present
US5298491A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 13, 1991 |
| Grant date | Mar 29, 1994 |
| Priority date | — |
| Expiry date | May 13, 2011 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/78
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Derivatives of biologically active molecules containing a primary amine group and a hydroxylated nucleus, and their addition salts with mineral or organic acids, having general formula I: EQU R'R"N--A--B--O--CH.sub.2 --CO--NH--R (I) PA0 A=linear or branched C.sub.1 -C.sub.5 alkylene; PA0 B=C.sub.4 -C.sub.10 aromatic nucleus with optional heteroatom, or=group --B.sub.1 --X--B.sub.2 --, wherein X=O or C.sub.1 -C.sub.4 alkylene; PA0 --NH--R=amine residue or alcohol residue; and PA0 R', R"=C.sub.1 -C.sub.5 alkyl, H or hydrophobic radical, and their addition salts with mineral or organic acids, method of preparation, applications, especially to visualization, purification, the preparation of antibodies and the assay of the total hormone, and as drugs, compositions in which they are present and analytical kits.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.