Diamino acid derivatives as antihypertensives
US5298492A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 4, 1992 |
| Grant date | Mar 29, 1994 |
| Priority date | — |
| Expiry date | Aug 4, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel diamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula ##STR1## wherein: Z is amino, lower alkylamino, di-(lower alkyl)amino R.sup.9 C(O)NH-- or an optionally substituted guanidino group; PA0 R.sup.1 is hydrogen or R.sup.7 R.sup.8 N--; PA0 R.sup.2 is hydrogen, lower alkyl, cyclolower alkyl, aryllower alkyl or heteroaryllower alkyl; and R.sup.3 is hydrogen, lower alkyl or cyclolower alkyl; or R.sup.2 and R.sup.3, together with the carbon to which they are attached, comprise a 3-7 membered carboxyclic ring; PA0 R.sup.4 is hydrogen, lower alkyl, aryl lower alkyl or heteroaryllower alkyl; PA0 R.sup.5 and R.sup.6 are independently hydroxy, lower alkoxy, amino, aryllower alkoxy, lower alkylamino and di-(lower alkyl)amino; PA0 R.sup.7 is R.sup.9 C(O)-- or R.sup.10 SO.sub.2 --; and R.sup.8 is hydrogen, lower alkyl, aryllower alkyl or aryl; or R.sup.7 and R.sup.8, together with the nitrogen to which they are attached, comprise a 5-7 membered ring; PA0 R.sup.9 is lower alkyl, aryllower alkyl, aryl, heteroaryllower alkyl, heteroaryl, lower alkoxy, aryllower alkoxy, amino, alkylamino or dialkylamino; PA0 R.sup.10 is lower alkyl, …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.