Method and composition for photodynamic treatment and detection of tumors
US5298502A · kind A · utility
29Cited by
11References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 23, 1991 |
| Grant date | Mar 29, 1994 |
| Priority date | — |
| Expiry date | Dec 23, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/535
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a method and a pharmaceutical composition for killing mammalian tumor cells by subjecting said cells to light in the presence of a light-activatable tetrapyrrole, in which the improvement comprises treating said cells with a compound which inhibits the enzymatic conversion of protoporphyrinogen to protoporphyrin IX by protoporphyrinogen oxidase in said cells thereby causing a buildup of protoporphyrin IX in said cells. Also disclosed is a method for the production of protoporphyrin IX which comprises growing eukaryotic microalgae in the presence of a protoporphyrinogen oxidase inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.