Alkanoic acid derivatives
US5298511A · kind A · utility
Assignees
Inventor
Key dates
| Filing date | Sep 23, 1992 |
| Grant date | Mar 29, 1994 |
| Priority date | — |
| Expiry date | Sep 23, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns alkanoic acid derivatives of the formula I ##STR1## wherein Ar.sup.1 is optionally-substituted phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur; PA0 A.sup.1 is a direct link to X.sup.1 or is (1-3 C)alkylene; PA0 X.sup.1 is oxy, thio, sulphinyl or sulphonyl; PA0 n is 0, 1 or 2 and R.sup.1 is halogeno, (1-4 C)alkyl, (1-4 C)alkoxy or fluoro-(1-4 C)alkyl; PA0 each of R.sup.2 and R.sup.3 is (1-4 C)alkyl, (2-4 C)alkenyl or (2-4 C)alkynyl; and PA0 R.sup.4 is hydrogen or (1-4 C)alkyl; PA0 or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.