GM-CSF protein, its derivatives, the preparation of proteins of this type, and their use

US5298603A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Paul Habermann · Solms, DE
• Hubert Mullner · Kelkheim, DE

Key dates

• Filing date: Dec 21, 1992
• Grant date: Mar 29, 1994
• Expiry date: Dec 21, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/145
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Expression of a gene coding for human granulocyte macrophage colony-stimulating factor (CSF) in bacteria results in CSF proteins which are biologically active. Modification of the natural or of a synthetic gene structure results in biologically active derivatives with a modified amino acid sequence.