Sucralose pentaester production

US5298611A · kind A · utility

Assignee

• McNeil-PPC, Inc. · US

Inventors

• Juan L. Navia · Doylestown, US
• Robert E. Walkup · Watkinsville, US
• Nicholas M. Vernon · Durham, US
• Robert E. Wingard, Jr. · Palo Alto, US

Key dates

• Filing date: Mar 12, 1993
• Grant date: Mar 29, 1994
• Expiry date: Mar 12, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H13/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for producing substantially pure sucralose pentaester from a mixture of 6-O-acyl-4,1' ,6' -trichloro-4,1',6'-trideoxygalactosucrose in a reaction medium comprising a tertiary amide, wherein said process comprises the steps of: PA1 (a) recovering the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose from said mixture; PA1 (b) peracylating the 6-O-acyl-4,1' ,6' -trichloro-4,1' ,6' -trideoxygalactosucrose product of step (a) to produce thereby 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester; and PA1 (c) crystallizing the 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester product of step (b) to produce substantially pure 4,1',6' -trichloro-4,1' ,6' -trideoxygalactosucrose pentaester.