Hybridoma cell line producing an antibody to type-I collagen amino-terminal telopeptide
US5300434A · kind A · utility
46Cited by
5References
2Claims
0Family size
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Key dates
| Filing date | Nov 21, 1990 |
| Grant date | Apr 5, 1994 |
| Priority date | — |
| Expiry date | Nov 21, 2010 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/108
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of determining collagen degradation in vivo, by quantitating the concentration of a peptide in a body fluid, the peptide being a C-terminal type II collagen telopeptide containing a hydroxylysyl pyridinoline cross-link or a type III collagen telopeptide containing a hydroxylysyl pyridinoline cross-link. Suitable methods include immunometric assays, fluorometric assays, and electrochemical titrations for quantitation. The structure of specific peptides having cross-links and kits for quantitating these peptides in a body fluid are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.