Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5300437A · kind A · utility
78Cited by
1References
16Claims
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Key dates
| Filing date | Oct 9, 1992 |
| Grant date | Apr 5, 1994 |
| Priority date | — |
| Expiry date | Oct 9, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P41/006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Amines in which the amino group is on a secondary carbon atom which is chirally substituted can be enantiomerically enriched by the action of an omega-amino acid transaminase which has the property of preferentially converting one of the two chiral forms to a ketone. The process also can be used to stereoselectively synthesize one chiral form from ketones substantially to the exclusion of the other.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.