5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5300499A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 2, 1992 |
| Grant date | Apr 5, 1994 |
| Priority date | — |
| Expiry date | Sep 2, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides novel carbonic anhyrase inhibitors represented by the structural formula: ##STR1## wherein R.sub.1 and R.sub.2 are, for example, independently (a) hydrogen; or PA0 (b) OR.sub.4, wherein R.sub.4 is hydrogen or C.sub.1-7 alkyl; or PA0 (c) NR.sub.5 R.sub.6, wherein R.sub.5 and R.sub.6 are independently hydrogen, or C.sub.1-7 alkyl, or C.sub.1-7 alkyl substituted with one or more halogen or OR.sub.4 ; or PA0 (d) --COR.sub.7, wherein R.sub.7 is hydrogen, C.sub.1-7 alkyl, or NR.sub.5 R.sub.6 ; or PA0 (e) --SR.sub.8, wherein R.sub.8 is hydrogen or C.sub.1-7 alkyl, or C.sub.1-7 alkyl substituted with one or more halogen, or OR.sub.4 ; or PA0 (f) C.sub.1-7 alkyl, or C.sub.1-7 alkyl substituted with one or more halogen, or OR.sub.4 or NR.sub.5 R.sub.6 ; or PA0 (g) R.sub.1 and R.sub.2 are together PA1 (i) .dbd.O, or PA1 (ii) .dbd.NOR.sub.8 or PA1 (iii) .dbd.S; and R.sub.3 is PA0 (h) C.sub.1-7 alkyl or C.sub.1-7 substituted with one or more halogen, OR.sub.4 or NR.sub.5 R.sub.6.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.