Indolylalkyl derivatives of pyrimidinylpiperazine for treating vascular headache

US5300506A · kind A · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• David W. Smith · Richmond, US
• Frank D. Yocca · Madison, US
• Joseph P. Yevich · Southington, US
• Ronald J. Mattson · Meriden, US
• Andrew Williams · Middletown, US
• Edward H. Ruediger · Saint-Lambert, CA

Key dates

• Filing date: Oct 13, 1992
• Grant date: Apr 5, 1994
• Expiry date: Oct 13, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A series of novel indol-3-ylalkyl derivatives of alkoxypyrimidinylpiperazines are disclosed as Formula I. ##STR1## These compounds are intended to be useful agents for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.