Process for the production of lactams
US5300649A · kind A · utility
5Cited by
1References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 3, 1992 |
| Grant date | Apr 5, 1994 |
| Priority date | — |
| Expiry date | Sep 3, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/86
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
.beta.,.gamma.-unsaturated .delta.-lactams, especially 2-azabicyclo[2.2.1]hept-5-en-3-one, are produced by Diels-Alder reaction of 1,3-dienes with sulfonyl cyanides and subsequent hydrolysis. The sulfonyl cyanides were formed in situ from cyanogen chloride and the corresponding sulfinates. By the renewed reaction of the sulfinate formed in the hydrolysis of the Diels-Alder adducts with cyanogen chloride, the sulfonyl cyanides are regenerated and a catalytic cyclic process results. The 2-azabicyclo[2.2.1]hept-5-en-3-one is a starting compound in the synthesis of antiviral nucleoside analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.