Ambulatory clearance function monitor
US5301673A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 18, 1991 |
| Grant date | Apr 12, 1994 |
| Priority date | — |
| Expiry date | Nov 18, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B2562/17
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Accurate and continuous monitoring of clearance function is obtained by determining the depletion of a labelled substance from the extracellular body fluid using an external monitor which detects label from within a defined tissue volume. The detector of the external monitor is contained within a collimator which functions to both exclude external influences and to functionally isolate the volume of extracellular fluid to be monitored. Also, a method for determining and expressing a clearance function in a subject includes steps of allowing a time sufficient to permit establishment of equilibrium of a detectable substance in the extracellular space in the subject, obtaining first and second measures, at first and second times, of the detectable substance in the extracellular fluid within a defined tissue volume in the subject, and determining the slope of the measures over the time interval.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.