Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents

US5302585A · kind A · utility

Assignees

• INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC · CZ
• REGA STICHTING, V.Z.W. · BE

Inventors

• Kuo-Long Yu · Hamden, US
• Joanne J. Bronson · Madison, US
• John C. Martin · Los Alamos, US

Key dates

• Filing date: Jul 22, 1992
• Grant date: Apr 12, 1994
• Expiry date: Jul 22, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65616
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides chiral nucleotide analogs having the Formulas I and II ##STR1## and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those caused by human immunodeficiency virus (HIV).