Sapphyrins, derivatives and syntheses
US5302714A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1992 |
| Grant date | Apr 12, 1994 |
| Priority date | — |
| Expiry date | Oct 26, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/101
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention involves, in addition to many unique substituted sapphyrins, a novel method for synthesizing sapphyrins with good efficiency and high yield. An improved 9-step synthesis of substituted sapphyrins, e.g., the two C.sub.2 symmetric sapphyrins, compounds 2 and 4 of FIG. 1C, is described herein. This synthesis involves as an important step the condensation between a tripyrrane diacid and a diformyl bipyrrole. The key tripyrrane component is prepared in three high-yield steps from readily available pyrrolic precursors and the bipyrrole portion is prepared in four steps from ethyl 3-methyl-4-methylpyrrole-2-carboxylate in roughly 33% yield overall.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.