Method of preparing a multiphase composition
US5304334A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 28, 1992 |
| Grant date | Apr 19, 1994 |
| Priority date | — |
| Expiry date | Apr 28, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S516/902
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention relates to methods of preparing and stabilizing complex multiphase compositions that include distinct phases of water, gel, liquid crystal or oil and perfluoropolyether dispersed in a continuous phase of a silicone fluid. In particular, the present invention relates to a method of preparing a stable multiphase composition comprising the steps of mixing an aqueous solution of a water-soluble polymeric emulsifier, a silicone-based emulsifier and an oleophobic, hydrophobic silicone fluid in amounts effective to form a stable water-in-silicone emulsion; mixing the water-in-silicone emulsion with a hydrophilic gel comprising a homogeneous mixture of water and a sufficient amount of at least one viscosity-enhancing, water-soluble polymer, the emulsion and gel being combined in amounts effective to form a dispersion in which the gel is dispersed in the emulsion; and adding to the dispersion an oil or a thermotropic liquid crystal and a perfluoropolyether in amounts effective to form a stable, multiphase composition comprising a continuous phase of silicone fluid and independent, polydisperse phases of water, gel, oil or liquid crystal and perfluoropolyether.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.