Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment

US5306718A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• David J. Lauffer · Saline, US
• Walter H. Moos · Ann Arbor, US
• Michael R. Pavia · Newton, US
• Haile Tecle · Ann Arbor, US
• Anthony J. Thomas · Ann Arbor, US

Key dates

• Filing date: Oct 16, 1991
• Grant date: Apr 26, 1994
• Expiry date: Oct 16, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds of the following general Formulas I, II and III are disclosed: ##STR1## Specifically the compounds are azabicyclo [2.2.1] omimes, azabicyclo [2.2.2] oximes, azabicyclo [2.2.1] amines, azabicyclo [2.2.2] amines, azabicyclo [3.2.1] oximes and amine containing heterocyclic oximes wherein the heterocyclic ring contains from 4 to 5 [3 to 7] carbon atoms.