Botulinum toxin neutralizer
US5306730A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 26, 1992 |
| Grant date | Apr 26, 1994 |
| Priority date | — |
| Expiry date | May 26, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/20
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A botulinum toxin neutralizer comprising at least one fatty acid having the number of carbon atoms of at least 12. Such a fatty acid may be any of saturated fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, nonadecanoic acid, arachidic acid, and behenic acid or any of unsaturated fatty acids such as oleic acid. The toxin neutralizer acts as if it were an antagonistic receptor for botulinum toxin and, when encountering botulinum toxin in human body, directly combines with the toxin and disables the toxin from combining with the neuromuscular tissues of human body to prevent the outbreak of botulism. The toxin thus neutralized and affixed to the botulinum toxin neutralizer is excreted from the human body. The botulinum toxin neutralizer can be manufactured easily and economically from a naturally occurring glyceride and is thus far less costly then the known antitoxin of ganglioside GT1b produced from bovine brain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.