Preparation process for arylacetic acids and their alkali metal salts
US5306833A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1993 |
| Grant date | Apr 26, 1994 |
| Priority date | — |
| Expiry date | Feb 3, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/377
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Process for obtaining an arylacetic acid of general formula (I): EQU Ar--CHR--COOH (I) in which R=H, C.sub.1 -C.sub.4 alk, Ar=2-thienyl, 3-thienyl, 1-naphthyl, 2-naphthyl, 1-(2-methoxy naphthyl), 3,4-methylenedioxy phenyl or phenyl of general formula (II): ##STR1## in which R.sub.1 =H, OH or C.sub.1 -C.sub.4 alkoxy, R.sub.2 =H, C.sub.1 -C.sub.4 alk, C.sub.1 -C.sub.4 alkoxy or OH, as well as their alkali metal salts, by reaction in a solvent of the corresponding arylglycolic acid of general formula (III): EQU Ar-CR(OH)--COOH (III) or one of its alkali metal salts with a hydrogen donor agent chosen from the group constituted by: formic acid, or one of its alkali metal salts, phosphonic acid, phosphinic acid, or one of their alkali metal salts, in the presence of a hydrogen transfer catalyst, which if desired is isolated or salified, and use for the preparation of certain acids of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.