Process for preparing pure L-.alpha.-glycerylphosphoryl-D-myoinositol and its salts
US5306840A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 5, 1992 |
| Grant date | Apr 26, 1994 |
| Priority date | — |
| Expiry date | Aug 5, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/117
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing pure L-alpha-Glycerylphosphoryl-D-Myoinositol and its salts consists of a) preparing the crude Na+ or K+ salt of L-.alpha.-Glycerylphosphoryl-D-Myoinositol, passing an aqueous solution of the salt through an acid resin in H form whereby ion exchange occurs and the acid L-.alpha.-Glycerylphosphoryl-D-Myoinositol is eluted by washing the resin with water. Then the aqueous solution is passed through a basic resin whereby the L-.alpha.-Glycerylphosphoryl-D-Myoinositol is adsorbed on the resin as the anion. The resin is eluted first with a dilute solution of formic, acetic or propionic acid and then eluted with a more concentrated solution of the same acid. The preparation of severals salts is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.