Chromatography processes using doped sol gel glasses as chromatographic media

US5308495A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• David Avnir · Jerusalem, IL
• Michael Ottolenghi · Jerusalem, IL
• Ovadia Lev · Jerusalem, IL

Key dates

• Filing date: Oct 11, 1991
• Grant date: May 3, 1994
• Expiry date: Oct 11, 2011

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N30/92
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Chromatography processes employ doped sol gel glasses as chromatographic media. In one embodiment, a process for qualitative or quantitative determination of a reactive chemical contained in a sample comprises passing the sample through a column or planar chromatography apparatus wherein the apparatus includes packing or plates containing a porous doped sol gel glass. The doped sol gel glass is formed form a metal alkoxide and contains a compound encapsulated therein which is reactive with the reactive chemical in the pores of the doped sol gel glass. In another embodiment, a process for analyzing a gas sample containing a reactive chemical comprises passing the gas sample through glass capillaries or tubes containing porous doped sol gel glass pellets. The pellets are formed from a metal alkoxide and contain a colorimetric reagent encapsulated therein which is reactive with the reactive chemical in the pores of the pellets. In a third embodiment, a doped sol gel glass is included in the chromatographic media for pretreatment cleanup for interference removal prior to the chromatographic separation.