Biocompatibility of solid surfaces
US5308641A · kind A · utility
148Cited by
11References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 19, 1993 |
| Grant date | May 3, 1994 |
| Priority date | — |
| Expiry date | Jan 19, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/31946
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylizine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.