Protein S chromogenic assay
US5308756A · kind A · utility
12Cited by
3References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 20, 1991 |
| Grant date | May 3, 1994 |
| Priority date | — |
| Expiry date | Nov 20, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/975
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A chromogenic assay for determination of Protein S, using an indicator of Factor Xa as a measure of Protein S concentration. This technique utilizes the dependency of activated Protein C on Protein S in order to inactivate a known portion of Factor VIII. Residual Factor VIII is then activated and acts with Factor IXa to activate Factor X. The chromogenic substrate is then cleaved by Factor Xa and the rate of conversion of the indicator molecule is an indirect indicator of free Protein S.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.