Method of inhibiting mammalian topoisomerase II and malignant cell growth in mammals, with substituted (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4 ]-benzoxazine(and-benzothiazine)-6-carboxylic acids
US5308843A · kind A · utility
1Cited by
7References
7Claims
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Key dates
| Filing date | Sep 11, 1990 |
| Grant date | May 3, 1994 |
| Priority date | — |
| Expiry date | Sep 11, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/54
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of inhibiting mammalian topoisomerase II and inhibiting the growth and inducing the regression of malignant cells in mammals by the action of a (S)-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine or -benzothiazine of the formula ##STR1## wherein R.sub.1 is hydrogen or fluoro, R.sub.2 and R.sub.3 each independently is hydrogen or alkyl having 1 to 4 carbon atoms, and X is O, S or S=O; a pharmaceutically acceptable acid-addition salt thereof; or a salt thereof with a pharmaceutically acceptable cation; and certain novel compounds of formula I.
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