Quinolylmethoxyphenyl-acetamides

US5310744A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Siegfried Raddatz · Hanerau-Hademarschen, DE
• Klaus-Helmut Mohrs · Wuppertal, DE
• Michael Matzke · Wuppertal, DE
• Romanis Fruchtmann · Cologne, DE
• Armin Hatzelmann · Konstanz, DE
• Reiner Muller-Peddinghaus · Bensberg, DE

Key dates

• Filing date: Nov 23, 1992
• Grant date: May 10, 1994
• Expiry date: Nov 23, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Quinolylmethoxyphenyl-acetamides of the formula: ##STR1## in which A, B, D, E, G, L and M are hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy or optionally substituted aryl; PA0 R.sub.1 represents optionally substituted cycloalkyl; and PA0 R.sub.2 and R.sub.3 independently represent hydrogen, alkyl, benzyl, or optionally substituted cycloalkyl; or together represent piperidinyl, morpholino, or piperazinyl; show a high in vitro activity as leukotriene synthesis inhibitors and, therefore, are suitable for the treatment and prevention of inflammations.