Somatotropins with alterations in the .alpha.-helix 3 region
US5310882A · kind A · utility
6Cited by
0References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Nov 30, 1990 |
| Grant date | May 10, 1994 |
| Priority date | — |
| Expiry date | Nov 30, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/12
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to somatotropin analogues with amino acid changes in the .alpha.-helix 3 regions of said somatotropins, changes in the .alpha.-helix 2 regions, combinations thereof plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release, formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptides also are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.