Fractionation of polyalkylene oxide-conjugated hemoglobin solutions
US5312808A · kind A · utility
61Cited by
3References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 13, 1992 |
| Grant date | May 17, 1994 |
| Priority date | — |
| Expiry date | Oct 13, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Hemoglobin-containing solutions containing polyalkylene oxide-conjugated hemoglobin having a molecular weight greater than about 85,000 daltons and a degree of substitution of at least five polyalkylene oxide conjugates per hemoglobin molecule are described that are not associated with hemoglobinuria in mammals. A method of simultaneously fractionating and purifying polyalkylene oxide-conjugated hemoglobins is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.