Indole derivatives
US5312829A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 6, 1992 |
| Grant date | May 17, 1994 |
| Priority date | — |
| Expiry date | Oct 6, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the formula: ##STR1## wherein R.sup.1 is carboxy or pharmaceutically acceptable salts and esters thereof; PA1 R.sup.2 is hydrogen, lower alkyl or halogen; PA1 R.sup.3 is phenyl, naphthyl, phenyl or naphthyl each substituted by from one to three C.sub.1-6 alkyl groups, mono-, di- or triphenyl (C.sub.1-6)alkyl; or substituted mono-, di- or triphenyl (C.sub.1-6) alkyl; PA1 A is lower alkylene which may be substituted by oxo or lower alkenylene, PA1 Q is carbonyl or lower alkylene, PA1 X is ##STR2## in which R.sup.4 is hydrogen or C.sub.1-6 alkyl, and PA2 R.sup.5 is hydrogen, C.sub.1-6 alkyl or Y--Z--R.sup.3, PA1 Y is a bond or lower alkylene, PA1 Z is lower alkylene ##STR3## in which R.sup.6 is hydrogen, (C.sub.1 -C.sub.6) alkyl, mono-, di- or triphenyl(C.sub.1-10) alkyl, C.sub.1-6 alkyl or lower alkoxycarbonyl substituted mono-, di- or triphenyl(C.sub.1-6)alkyl or pharmaceutically acceptable carboxylic acid acyl, and pharmaceutically acceptable salts thereof. The compound is useful as a testosterone 5.alpha.-reductase inhibitor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.