Bis- and tetrakis-phosphonates useful for treating calcium related disorders

US5312954A · kind A · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Eli Breuer · Jerusalem, IL
• Gershon Golomb · Beer Sheva, IL

Key dates

• Filing date: May 13, 1992
• Grant date: May 17, 1994
• Expiry date: May 13, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/405
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel bisphosphonates comprise compounds of the formula (I) ##STR1## wherein m and l are independently 1 or 2; R.sub.1 represents hydrogen, a lower alkyl group, or an alkali metal cation; R.sub.2 represents hydrogen, a lower alkyl group or an alkali metal cation; Y represents .dbd.0 or .dbd.N--OH, or --OH and X represents --(CH.sub.2).sub.n --, a branched alkylene group, or a branched or straight alkenylene or alkynylene chain optionally substituted by one or more oxygen or nitrogen atoms, wherein n is an integer from 3 to 24. Further definitions of X are included in the description.