Patent · US Expired

2-amino-7-hydroxytetralin carboxylalkyl ethers

US5312961A · kind A · utility

4Cited by

2References

4Claims

0Family size

Assignee

Societe Anonyme: Elf Sanofi · FR

Inventors

Umberto Guzzi · Milano, IT
Roberto Cecchi · Lodi, IT
Luciano Manara · Alessandria, IT

Key dates

Filing date	Jun 29, 1992
Grant date	May 17, 1994
Priority date	—
Expiry date	Jun 29, 2012

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2602/10
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to 2-amino-7-hydroxytetralin carboxyalkyl ethers of formula ##STR1## wherein Alk represents a straight or branched (C.sub.3 -C.sub.5)alkylene group, and R is hydrogen or (C.sub.1 -C.sub.4)alkyl, useful as starting materials in the synthesis of 7-substituted phenylethanolaminotetralins of formula (XII) ##STR2## wherein X represents hydrogen, halogen, (C.sub.1 -C.sub.4)alkyl, or trifluoromethyl which are useful as spasmolytics and anti-glaucoma agents. The new 7-substituted phenylethanolaminotetralins (XII) as well as the intermediates in the preparation of the compounds (I), the N-protected 2-amino-7-hydroxytetralin carboxyalkyl ethers, are also claimed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.